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Following the events in Incarnate: Existence, the handful of desperate freedom fighters known as the forty-eights, led by an immortal being who is reincarnated every time they die, are indelibly transformed by what happened. Beset by violent insurgents, mounting corporate influences, frantic ideological governments, and a group of zealous hackers known as the Anonymous Knights, our protagonist attempts to hold the forty-eights together, even as their own mind seems to be coming apart. Propelled into an unfamiliar future where advanced technology can alter the very genetics of a human being, where the scourge of a new drug called Shift threatens to become an epidemic, and where global conspiracies endeavor to steer the tides of destiny, our protagonist will continue seeking answers to their own puzzling existence as a possible way to ensure a better future for humanity. In this second installment of the five part Incarnate series, old and new allies join our protagonist, no matter what body they come to inhabit. In Incarnate: Essence, success is grim, but failure is not an option.